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CAR-T Cell Therapy Project CAR-NK Cell Therapy Project TCR-T Oncolytic virotherapy

CAR-T Cell Therapy Project

1. Basic principle of CAR-T cell therapy


The CAR-T cell therapy is a gene engineering technology. It first transforms a fragment of scFv, an antibody capable of recognizing a tumor-specific antigen, then integrates the fragment into the transmembrane chain segment consisting of a series of molecules involved in T cell activation such as CD28, 4-1BB and CD3-ζ, forming a recombinant plasmid CAR. The CAR will be transduced into the T cells of a patient and cause them to express CAR. After the “re-coding”, a large amount of tumor-specific CAR-T cells will be generated to attack and eventually ablate the tumor.


2. Advantages of CAR-T cell therapy